GH AXIS

The GH axis — GHRH, somatostatin, IGF-1

TARA Research Desk · 2026-07-20 · 6 min read

Research & laboratory use only

This article supports qualified researchers. It is not medical advice and must not be used to plan human or veterinary administration.

Hypothalamic GHRH stimulates pituitary GH release; somatostatin inhibits it. GH acts directly and via hepatic IGF-1. Secretagogue research compounds act at different nodes of this axis — understanding the map prevents treating all “GH peptides” as interchangeable.

Separate GHRH-receptor analogues from ghrelin-receptor (GHRP) ligands in your notes.
Remember pulsatility: many assays care about sampling relative to a pulse, not a flat “daily dose” metaphor from forums.

Further study

External links are educational. Prefer institutional and peer-reviewed sources; ignore any “home injection” framing on third-party pages.

Video: Ninja Nerd — Growth Hormone (physiology lecture)Endocrine physiology only — not peptide administration guidance.

Primary literature

Ipamorelin, the first selective growth hormone secretagogueEuropean Journal of Endocrinology (1998)
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormoneJournal of Clinical Endocrinology & Metabolism (2006)

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